Key result
Three-dimensional morphological analysis of a PVOD lung explant revealed multifocal intussusceptive neoangiogenesis and vascular sprouting as the correlate of progressive pulmonary capillary hemangiomatosis.
Why the study?
The underlying mechanisms of aberrant remodeling processes in pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis remain poorly understood.
Population
Lung explant of 1 patient diagnosed with PVOD
Authors
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Hypothesis-generating in PVOD; larger studies needed before clinical or therapeutic implications.
Case Report (n=1)
No
This study provides novel 3D morphological evidence that progressive pulmonary capillary hemangiomatosis in PVOD is driven by intussusceptive neoangiogenesis, likely induced by increased shear forces from venous occlusions.
Neubert et al. (2019) conducted a case report in Pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis (n=1). Three-dimensional morphological analysis of a PVOD lung explant revealed multifocal intussusceptive neoangiogenesis and vascular sprouting as the correlate of progressive pulmonary capillary hemangiomatosis.
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