Key result
The KCNE1 polymorphism rs1805127 was associated with Ménière's disease in sporadic patients (p=0.011), but not in familial patients (p=0.62).
Why the study?
Are variations in candidate genes (AQP2, KCNE1, KCNE3, HCFC1, COCH, ADD1) associated with Ménière's disease in Finnish patients?
Population
38 sporadic and 21 familial Finnish Ménière's disease patients
Comparison
Genetic analysis of six candidate genes vs Control group
Design
Case-control
Authors
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No practice change indicated for Ménière's disease; leaves open a KCNE1 role requiring validation in larger cohorts.
Case-Control (n=59)
Are variations in candidate genes (AQP2, KCNE1, KCNE3, HCFC1, COCH, ADD1) associated with Ménière's disease in Finnish patients?
p-value: p=0.011
The study identified an association between the KCNE1 polymorphism rs1805127 and sporadic Ménière's disease, highlighting the need for more comprehensive genetic studies.
Hietikko et al. (2012) conducted a case-control in Ménière's disease (n=59). Genetic mutation analysis (AQP2, KCNE1, KCNE3, HCFC1, COCH, ADD1) was evaluated on Genetic association with Ménière's disease (p=0.011). The KCNE1 polymorphism rs1805127 was associated with Ménière's disease in sporadic patients (p=0.011), but not in familial patients (p=0.62).
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