Oral supplementation with the mitochondrial antioxidant MitoQ (20 mg/d) for 6 weeks improved brachial artery flow-mediated dilation by 42% compared to placebo in healthy older adults (P<0.05).
RCT (n=20)
double-blind
crossover
Does oral supplementation with MitoQ improve vascular endothelial function in healthy older adults with impaired endothelial function?
Six weeks of oral MitoQ supplementation significantly improved brachial artery flow-mediated dilation and reduced aortic stiffness in healthy older adults with impaired endothelial function.
Effect estimate: 42% higher
p-value: p=<0.05
Excess reactive oxygen species production by mitochondria is a key mechanism of age-related vascular dysfunction. Our laboratory has shown that supplementation with the mitochondrial-targeted antioxidant MitoQ improves vascular endothelial function by reducing mitochondrial reactive oxygen species and ameliorates arterial stiffening in old mice, but the effects in humans are unknown. Here, we sought to translate our preclinical findings to humans and determine the safety and efficacy of MitoQ. Twenty healthy older adults (60–79 years) with impaired endothelial function (brachial artery flow–mediated dilation 7.60 m/s; n=11). Plasma oxidized LDL (low-density lipoprotein), a marker of oxidative stress, also was lower after MitoQ versus placebo ( P 0.1). These findings in humans extend earlier preclinical observations and suggest that MitoQ and other therapeutic strategies targeting mitochondrial reactive oxygen species may hold promise for treating age-related vascular dysfunction. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT02597023.
Rossman et al. (Mon,) conducted a rct in impaired endothelial function (n=20). MitoQ vs. placebo was evaluated on Brachial artery flow-mediated dilation (42% higher, p=<0.05). Oral supplementation with the mitochondrial antioxidant MitoQ (20 mg/d) for 6 weeks improved brachial artery flow-mediated dilation by 42% compared to placebo in healthy older adults (P<0.05).