What does this research mean for the field?

Episodes of Prinzmetal's variant angina are not triggered by increased cardiac work or oxygen demand, but instead cause significant left ventricular impairment that correlates with the severity of electrocardiographic abnormalities. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Characterize the dynamic hemodynamic alterations and left ventricular performance before, during, and after spontaneous episodes of Prinzmetal's variant angina.

January 1, 1971HeartOpen Access

Left ventricular performance and related haemodynamic changes in Prinzmetal's variant angina pectoris

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Why the study?

What are the haemodynamic changes associated with episodes of Prinzmetal's variant angina pectoris?

Key Points

Characterize the dynamic hemodynamic alterations and left ventricular performance before, during, and after spontaneous episodes of Prinzmetal's variant angina.
Continuously monitored electrocardiograms, arterial pressure, right atrial pressure, and heart rate for 5 to 7 hours in N=4 patients.
Measured cardiac output, isovolumic contraction time, systolic ejection rate, and ejection time across 38 recorded anginal episodes.
No circulatory changes or alterations in cardiac workload preceded the onset of electrocardiographic abnormalities.
Active episodes produced acute left ventricular impairment marked by reduced cardiac output, arterial hypotension, prolonged isovolumic contraction time, and decreased systolic ejection rate.
Hemodynamic recovery occurred rapidly within approximately 2 minutes following a transient supernormal phase, with chest pain functioning as a concomitant symptom rather than a hemodynamic driver.

Structured PICO

What are the haemodynamic changes associated with episodes of Prinzmetal's variant angina pectoris?

Population

4 patients with Prinzmetal's variant angina pectoris

Intervention

Continuous haemodynamic and electrocardiographic monitoring for 5 to 7 hours

Outcome

Haemodynamic changes (cardiac output, arterial pressure, left ventricular ejection time, isovolumic contraction time, mean rate of isovolumic pressure development, mean systolic ejection rate) during anginal episodessurrogate

Prinzmetal's variant angina episodes are accompanied by significant, transient left ventricular impairment that correlates with electrocardiographic changes rather than preceding circulatory triggers.

Discussion

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Implication

Alerts clinicians to monitor LV function during variant angina; leaves open mechanisms in larger prospective cohorts.

Cite This Study

Guazzi et al. (1971) studied this question.

synapsesocial.com/papers/6a1b38465853c704fce592ab https://doi.org/10.1136/hrt.33.1.84

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Left ventricular performance and related haemodynamic changes in Prinzmetal's variant angina pectoris

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Left ventricular performance and related haemodynamic changes in Prinzmetal's variant angina pectoris

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider