A side‐by‐side diffusion cell was used to study the permeability of glucose through a temperature‐ and pH‐sensitive poly( N ‐isopropylacrylamide‐ co ‐methacrylic acid) hydrogel membrane. At fixed temperature (37°C), lowering pH in one side of the cell induced hydrogel volume collapse and strongly attenuated glucose permeation across the membrane. Hysteresis was observed in the glucose permeability versus pH characteristic.
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Baker et al. (1996) studied this question.
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