Key result
The rs184003 T allele in the RAGE gene was significantly more frequent in acute coronary syndrome patients than in healthy controls (28.87% vs. 11.25%; OR 3.2; 95% CI 1.86-5.52; p<0.0001).
Why the study?
Do RAGE gene polymorphisms (rs2070600 G/A and rs184003 G/T) predispose individuals to acute coronary syndrome in the Polish population?
Case-Control
Do RAGE gene polymorphisms (rs2070600 G/A and rs184003 G/T) predispose individuals to acute coronary syndrome in the Polish population?
Odds Ratio: 3.2 (95% CI 1.86–5.52)
Absolute Event Rate: 28.87% vs 11.25%
p-value: p=<0.0001
The rs184003 SNP in the RAGE gene is associated with an increased genetic susceptibility to acute coronary syndrome in the Polish population.
BACKGROUND: The development of coronary artery disease (CAD) is the result of complex interactions between environmental and genetic factors. While the former is well known, the genetic factors that predispose individuals to the development of CAD are still under investigation. The aim of our study was to investigate whether single nucleotide polymorphisms (SNPs) in the gene encoding the receptor for advanced glycation end products (RAGE), specifically rs2070600 G/A and rs184003 G/T, may determine predisposition to acute coronary syndrome (ACS) and severity of coronary artery disease (CAD) in the Polish population. METHODS: test on a 2 × 2 contingency table. Genotype distribution was analyzed assuming three modes of inheritance: dominant, codominant, or recessive. The values of the variables between the study groups were compared using Student's t-test or the Mann-Whitney U test, as appropriate. RESULTS: For the rs184003 G/T polymorphism, the frequency of genotypes containing the T allele (GT + TT) was significantly greater in patients with a history of ACS than in healthy age- and sex-matched controls (28.87% vs. 11.25%, p < 0.0001, OR = 3.2 [95% CI: 1.86-5.52]). Moreover, individuals possessing this allele had lower high-density lipoprotein (HDL) cholesterol levels (mean 1.02 mmol/l vs. 1.14 mmol/l, p = 0.01) and higher median troponin I concentrations at the time of ACS (32.2 ng/ml vs. 24.4 ng/ml, p = 0.04). These genotypes were also significantly less common in patients with ACS before the age of 50 than in those diagnosed later (20.0% vs. 38.5%, p = 0.0002, OR = 0.4 [95%CI: 0.25-0.65]). In the case of rs2070600 G/A polymorphism, the genotype and allele frequencies were not significantly different between the study groups and subgroups. CONCLUSIONS: Our findings suggest that the rs184003 SNP in the RAGE gene may play a role in determining genetic susceptibility to CAD and ACS in the Polish population. However, they do not support the hypothesis that the studied SNPs impact the incidence of ACS at a young age.
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Gutowska et al. (2025) conducted a case-control in Acute coronary syndrome (ACS). rs184003 G/T polymorphism (T allele) vs. Healthy age- and sex-matched controls was evaluated on Frequency of genotypes containing the T allele (GT + TT) for the rs184003 G/T polymorphism (OR 3.2, 95% CI 1.86-5.52, p=<0.0001). The rs184003 T allele in the RAGE gene was significantly more frequent in acute coronary syndrome patients than in healthy controls (28.87% vs. 11.25%; OR 3.2; 95% CI 1.86-5.52; p<0.0001).
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