Key result
A case series of three adolescents with tuberculous pericarditis described their clinical outcomes following pericardiocentesis and medical therapy.
Why the study?
Tuberculous pericarditis carries high mortality without adequate therapy, and adolescents are at the highest risk of having tuberculosis.
Case Report (n=3)
This case series reports on the clinical outcomes of three adolescents with tuberculous pericarditis managed with pericardiocentesis and medical therapy.
Answers are grounded in this paper and cite their sources.
Adds limited evidence on adolescent tuberculous pericarditis outcomes; hypothesis-generating and requires prospective validation before practice change.
Tuberculosis (TB) is one of the major causes of childhood mortality, especially in endemic areas. In 2013, the World Health Organization (WHO) estimated 550,000 new cases and 80,000 deaths due to TB among children. Around 70-80% of the cases were pulmonary TB, while the rest were extra-pulmonary TB.1 Tuberculous pericarditis accounts for only 8% of all TB cases, however, tuberculosis is the main cause of pericarditis in high-TB-burden countries, including Indonesia.2 The mortality rate reached 17-40% and is affected by treatment adequacy.3 Without adequate therapy, the mean life expectancy is 3.7 months, with only 20% surviving to the sixth month.4 A 2004 study reported that successful treatment of TB in children depends on several factors, such as treatment compliance, timing and accuracy of diagnosis, concurrent human immunodeficency virus (HIV) infection and its clinical stage of disease, malnutrition, and drug resistance.5 Adolescents and young adults are at the highest risks of having TB.6 We report here on three cases of tuberculous pericarditis in adolescents and their outcomes following pericardiocentesis and medication.
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Paramitha et al. (2020) conducted a case report in Tuberculous pericarditis (n=3). Pericardiocentesis and medication was evaluated on Clinical outcomes. A case series of three adolescents with tuberculous pericarditis described their clinical outcomes following pericardiocentesis and medical therapy.
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