Key result
Combined CDH13 and VCAM-1 expression predicts severe CAD better than single genes with ~90% sensitivity.
Why the study?
Although T-cadherin and VCAM-1 are associated with STEMI, their relationship and the ability of their gene expression to predict CAD prognostic outcomes in acute STEMI needed evaluation.
Does combined CDH13 and VCAM-1 gene expression predict the occurrence of MACE and the extent of CAD in patients with acute STEMI?
Case-Control (n=150)
No
Does combined CDH13 and VCAM-1 gene expression predict the occurrence of MACE and the extent of CAD in patients with acute STEMI?
Answers are grounded in this paper and cite their sources.
Combined measurement of CDH13 and VCAM-1 gene expression may serve as a useful biomarker for predicting the severity of coronary artery disease and the 6-month risk of major adverse cardiac events in patients with acute STEMI.
Background T-cadherin, encoded by the CDH13 gene, has a significant relationship with atherosclerosis and coronary heart disease (CHD) initiation and progression. Vascular cell adhesion molecule-1 (VCAM-1) plays an essential role in endothelial inflammation. Both T-cadherin and VCAM-1 were associated with the occurrence of ST-elevation myocardial infarction (STEMI). Objective We aimed to find the relationship between CDH13 and VCAM-1 gene expression in STEMI and to evaluate the ability of their gene expression to predict the prognostic outcome of coronary artery disease (CAD) in acute STEMI. Methods This case-control study enrolled 150 participants: 75 patients with STEMI and 75 healthy controls. A follow-up of patients for 6 months was performed. The participants were compared regarding CDH13 and VCAM-1 gene expression, as well as their 6-month clinical outcome. Results CDH13 and VCAM-1 were significantly elevated in patients with STEMI. Additionally, combined gene expression was significantly superior to single gene expression in predicting the extent of CAD with a Gensini score ≥ 20 at a cut-off value of 5.12 with a sensitivity of 89.5%. Conclusion Combining CDH13 and VCAM-1 expression is more valuable than using them individually in predicting the occurrence of major cardiac events (MACE) and predicting the extent of CAD.
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Wageeh et al. (2025) conducted a case-control in ST-elevation myocardial infarction (STEMI) (n=150). Combined CDH13 and VCAM-1 gene expression vs. Single gene expression was evaluated on Prediction of severe CAD (Gensini score ≥ 20) (AUC 0.689, p=0.006). Combined expression of CDH13 and VCAM-1 was significantly superior to single gene expression in predicting severe coronary artery disease (Gensini score ≥ 20) with a sensitivity of 89.5%.
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