Key result
Higher plasma homocysteine levels on admission were significantly correlated with increased severity of coronary artery disease as measured by the SYNTAX score (r=0.166, p<0.01).
Why the study?
Are elevated homocysteine levels associated with increased severity of coronary artery disease as determined by the SYNTAX score in patients with acute coronary syndrome?
Observational (n=503)
Are elevated homocysteine levels associated with increased severity of coronary artery disease as determined by the SYNTAX score in patients with acute coronary syndrome?
Serum homocysteine levels on admission are positively correlated with the angiographic severity of coronary artery disease in patients presenting with acute coronary syndrome.
BACKGROUND: Hyperhomocysteinemia is a known risk factor for acute coronary syndrome (ACS) and is related with the severity of coronary artery disease (CAD). Previous studies have used less quantifiable scoring systems for assessing the severity of CAD. Therefore, we aimed to assess the relationship between homocysteine levels and SYNTAX score (SXscore), which is currently more widely used to grade the severity of CAD. METHODS: A total of 503 patients with adiagnosis of ACS were examined angiographically with SXscore. The patients were divided into three groups according to SXscore; Group 1 a low SXscore (≤ 22), Group 2 a moderate SXscore (23-32), and Group 3 a high SXscore (≥ 33). RESULTS: Plasma homocysteine levels were 16.3 ± 6.2 nmol/mL in Group 1, 18.1 ± 9.6 nmol/mL in Group 2, and 19.9 ± 9.5 nmol/mL in Group 3. Homocysteine levels were significantly higher in Group 2, and Group 3 compared to Group 1 (p = 0.023 and 0.007, respectively). In the correlation analysis, homocysteine levels were correlated with SXscore (r: 0.166, p < 0.01). CONCLUSIONS: Serum homocysteine levels on admission were associated with an increased severity of CAD in the patients with ACS.
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Karadeniz et al. (2018) conducted an observational in Acute coronary syndrome (n=503). Plasma homocysteine levels was evaluated on Relationship between homocysteine levels and SYNTAX score (r 0.166, p=<0.01). Higher plasma homocysteine levels on admission were significantly correlated with increased severity of coronary artery disease as measured by the SYNTAX score (r=0.166, p<0.01).
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