What question did this study set out to answer?

To determine whether baseline high-sensitivity C-reactive protein (hs-CRP) levels are associated with the anatomical complexity and burden of coronary atherosclerosis assessed by the SYNTAX score in patients with acute coronary syndrome.

January 1, 2015International Heart JournalOpen Access

High Sensitive CRP Level Is Associated With Intermediate and High Syntax Score in Patients With Acute Coronary Syndrome

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Why the study?

Does elevated baseline hs-CRP predict a higher SYNTAX score in patients with acute coronary syndrome?

Key Points

To determine whether baseline high-sensitivity C-reactive protein (hs-CRP) levels are associated with the anatomical complexity and burden of coronary atherosclerosis assessed by the SYNTAX score in patients with acute coronary syndrome.
Enrolled 321 patients with acute coronary syndrome (N=321) undergoing coronary angiography.
Stratified patients into low (≤ 22) and intermediate-to-high (≥ 23) SYNTAX score groups.
Performed multivariate logistic regression to identify independent predictors of a high SYNTAX score.
Patients in the intermediate-high SYNTAX score group exhibited significantly higher serum hs-CRP levels than those in the low group (7.7 ± 3.4 mg/L vs. 4.9 ± 2.5 mg/L, P < 0.001).
Multivariate logistic regression revealed that elevated hs-CRP (OR: 1.14), multivessel disease (OR: 0.23), left ventricular ejection fraction (OR: 0.90), and troponin levels (OR: 1.12) independently predicted a high SYNTAX score.

Structured PICO

Does elevated baseline hs-CRP predict a higher SYNTAX score in patients with acute coronary syndrome?

Population

321 patients with acute coronary syndrome (STEMI n=224, 69.8%; NSTE-ACS n=97, 30.2%) who underwent coronary angiography. Exclusions: SYNTAX score of zero, prior CABG, CPR before admission, advanced valve disease, advanced renal/hepatic disease, known malignancy, history of congestive heart failure, and/or overt pump failure (≥ Killip class III) on admission.

Intervention

Elevated baseline high sensitive C-reactive protein (hs-CRP) levels on admission

Comparator

Lower baseline hs-CRP levels

Outcome

Intermediate-high SYNTAX score (≥ 23) indicating severe and complex coronary atherosclerosissurrogate

Elevated baseline hs-CRP levels in patients with acute coronary syndrome are independently associated with a higher SYNTAX score, indicating more severe and complex coronary atherosclerosis.

Limitations

The assessment of coronary angiographic lesions is a technique that detects only major coronary arterial lesions.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Elevated hs-CRP may signal complex CAD in ACS; hypothesis-generating and should not yet change practice.

Cite This Study

Karadeniz et al. (2015) studied this question.

synapsesocial.com/papers/6a7e428f971946435f4f9a2a https://doi.org/10.1536/ihj.14-299

Topics

Coronary artery disease

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High Sensitive CRP Level Is Associated With Intermediate and High Syntax Score in Patients With Acute Coronary Syndrome

Key Points

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Topics

High Sensitive CRP Level Is Associated With Intermediate and High Syntax Score in Patients With Acute Coronary Syndrome

Key Points

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider