What does this research mean for the field?

Trypanosomatid U2 RNAs possess a unique secondary structure that differs from previous consensus models by forming only two helices in the stem-loop II region, eliminating pseudoknot formation, and having highly divergent branchpoint recognition sequences. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

December 1, 1990Genes & DevelopmentOpen Access

A new U2 RNA secondary structure provided by phylogenetic analysis of trypanosomatid U2 RNAs.

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Population

U2 RNA sequences from distantly related trypanosomatids and cis-splicing organisms

Design

Preclinical

Authors

THToinette HartshorneAdvanced Genetic Systems (United States)NANina AgabianUniversity of Iowa

Discussion

Member takes

Implication

Challenges prior U2 RNA models from cis-splicing organisms; leaves open trypanosomatid-specific trans-splicing mechanisms.

Structured PICO

Population

U2 RNA sequences from distantly related trypanosomatids and cis-splicing organisms

Intervention

Phylogenetic analysis and sequence comparison

Outcome

U2 RNA secondary structure model

Phylogenetic analysis reveals a new U2 RNA secondary structure in trypanosomatids with altered stem-loop II and branchpoint recognition sequences.

Cite This Study

Hartshorne et al. (1990) studied this question.

synapsesocial.com/papers/6a1b44e2db618aee6aabada2 https://doi.org/10.1101/gad.4.12a.2121

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A new U2 RNA secondary structure provided by phylogenetic analysis of trypanosomatid U2 RNAs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A new U2 RNA secondary structure provided by phylogenetic analysis of trypanosomatid U2 RNAs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider