Why the study?
Does 99Tcm-gluconate uptake correlate with histologic findings of early myocardial infarction in dogs?
Does 99Tcm-gluconate uptake correlate with histologic findings of early myocardial infarction in dogs?
99Tcm-gluconate shows promise as an imaging agent for detecting early myocardial infarction, correlating well with histologic findings in a canine model.
Hypothesis-generating for 99Tcm-gluconate in early MI imaging; leaves open clinical translation beyond canine models.
A new isotope, 99Tcm-gluconate, for detection of myocardial infarction has been investigated experimentally. Great differences in isotope uptake between infarcted myocardium and normal myocardium were found in dogs. A close correlation was found between the isotope uptake and the uptake of basic fuchsin (HBFP) at microscopy in early myocardial infarcts.
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Ahlberg et al. (1978) studied this question.
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