Key result
Preoperative left ventricular dysfunction did not significantly increase the risk of postoperative Expanded MACE compared to normal ventricular function (8.3% vs 7.0%, OR 1.198).
Why the study?
Peripheral artery disease and cardiac disease are often comorbid, and it was hypothesized that preoperative echocardiographic ventricular dysfunction and valvular lesions are associated with increased Expanded MACE following vascular surgery.
Do preoperative echocardiographic findings of ventricular dysfunction or valvular lesions predict postoperative Expanded MACE in patients undergoing vascular surgery?
Cohort (n=813)
No
Do preoperative echocardiographic findings of ventricular dysfunction or valvular lesions predict postoperative Expanded MACE in patients undergoing vascular surgery?
Effect estimate: OR 1.198 (95% CI 0.712-2.015)
Absolute Event Rate: 8.3% vs 7%
p-value: p=0.496
Preoperative echocardiographic findings of ventricular dysfunction or moderate-to-severe valvular lesions were not predictive of postoperative Expanded MACE in contemporary vascular surgery patients, likely reflecting the transition to endovascular techniques and improved perioperative care.
Does not support routine preoperative echo for MACE risk stratification in vascular surgery; leaves open its value in open procedures or other cohorts.
INTRODUCTION: Peripheral artery disease and cardiac disease are often comorbid conditions. Echocardiography is a diagnostic tool that can be performed preoperatively to risk stratify patients by a functional cardiac test. We hypothesized that ventricular dysfunction and valvular lesions were associated with an increased incidence of expanded major adverse cardiac events (Expanded MACE). METHODS AND MATERIALS: Retrospective cohort study from 2011 to 2020 including all patients from a major academic center who had vascular surgery and an echocardiographic study within two years of the index procedure. RESULTS: 813 patients were included in the study; a majority had a history of smoking (86%), an ASA score of 3 (65%), and were male (68%). Carotid endarterectomy was the most common surgery (24%) and the least common surgery was open abdominal aortic aneurysm repair (5%). We found no significant association between the echocardiographic findings of left ventricular dysfunction, right ventricular dysfunction, or valvular lesions and the postoperative development of Expanded MACE. CONCLUSIONS: The preoperative echocardiographic findings of left ventricular dysfunction, right ventricular dysfunction and moderate to severe valvular lesions were not predictive of an increased incidence of postoperative Expanded MACE. We identified a significant association between RV dysfunction and post-operative dialysis that should be interpreted carefully due to the small number of outcomes. The transition from open to endovascular surgery and advances in perioperative management may have led to improved cardiovascular outcomes. TRIAL REGISTRATION: Trial Registration: NCT04836702 (clinicaltrials.gov). https://www.google.com/search?client=firefox-b-d&q=NCT04836702.
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Meyer et al. (2023) conducted a cohort in Vascular surgery (n=813). Left ventricular dysfunction vs. Normal left ventricular function was evaluated on Expanded major adverse cardiac events (Expanded MACE) (OR 1.198, 95% CI 0.712-2.015, p=0.496). Preoperative left ventricular dysfunction did not significantly increase the risk of postoperative Expanded MACE compared to normal ventricular function (8.3% vs 7.0%, OR 1.198).
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