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Summarize current evidence on neurodegenerative biomarkers to enable earlier and more objective detection of conversion from relapsing-remitting to secondary progressive multiple sclerosis.

September 12, 2023Frontiers in Molecular NeuroscienceOpen Access

Neurodegeneration and its potential markers in the diagnosing of secondary progressive multiple sclerosis. A review

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Authors

APAleksandra Pogoda-WesołowskaWojskowy Instytut Medyczny ADAngela DziedzicUniversity of Łódź KMKarina MaciakUniversity of Łódź

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Implication

Narrative review highlights biomarkers of neurodegeneration in multiple sclerosis, suggesting objective tools to reduce diagnostic delays in progressive disease.

Key Points

Summarize current evidence on neurodegenerative biomarkers to enable earlier and more objective detection of conversion from relapsing-remitting to secondary progressive multiple sclerosis.
Review of clinical diagnostic challenges, retrospective disability assessment frameworks, and disease milestones in multiple sclerosis.
Synthesis of molecular and pathological markers associated with persistent neurodegeneration and neuroinflammation during secondary progressive disease transition.
Approximately 70% of patients with relapsing-remitting multiple sclerosis convert to secondary progressive multiple sclerosis within 10 to 15 years.
Current diagnostic reliance on retrospective physical disability assessments over 6 to 12 months causes a clinical diagnosis delay of up to 3 years.
Objective neurodegenerative biomarkers present a viable pathway to eliminate diagnostic lag and facilitate timely administration of disease-modifying therapy.

Cite This Study

Pogoda-Wesołowska et al. (2023) studied this question.

synapsesocial.com/papers/6a1b67c9947c651ddaabd6cc https://doi.org/10.3389/fnmol.2023.1210091

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Implication

Narrative review highlights biomarkers of neurodegeneration in multiple sclerosis, suggesting objective tools to reduce diagnostic delays in progressive disease.

Neurodegeneration and its potential markers in the diagnosing of secondary progressive multiple sclerosis. A review

Discussion

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Implication

Key Points

Cite This Study

Neurodegeneration and its potential markers in the diagnosing of secondary progressive multiple sclerosis. A review

Discussion

Member takes

Implication

Key Points

Cite This Study

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