Key result
A CHA2DS2-VASc score ≥2 was associated with a significantly higher rate of atrial fibrillation recurrence after catheter ablation compared to a score <2 (31.6% vs. 18.1%, p=0.046).
Why the study?
Does a CHA2DS2-VASc score ≥2 predict atrial fibrillation recurrence in patients with non-valvular atrial fibrillation undergoing catheter ablation?
Cohort (n=151)
Does a CHA2DS2-VASc score ≥2 predict atrial fibrillation recurrence in patients with non-valvular atrial fibrillation undergoing catheter ablation?
Absolute Event Rate: 31.6% vs 18.1%
p-value: p=0.046
A CHA2DS2-VASc score ≥2 is associated with greater atrial remodeling and a higher risk of atrial fibrillation recurrence following a single catheter ablation.
Higher CHA2DS2-VASc scores may flag elevated post-ablation recurrence risk; leaves open its utility for patient selection or trial enrichment.
Background and Objectives This study aimed to evaluate the impact of the CHA2 DS2-VASc score on atrial fibrillation (AF) recurrence after a single catheter ablation procedure in patients with non-valvular AF. We also investigated the correlation between CHA2 DS2-VASc score and atrial substrate. Subjects and Methods This study evaluated 151 patients who underwent catheter ablation of non-valvular AF. The study population was stratified into group 1 (<2, n=72) and group 2 (≥2, n=79) by CHA2 DS2-VASc score. The CHA2 DS2-VASc score was analyzed as a continuous and categorical value for evaluating its impact on AF recurrence after catheter ablation. The left atrial voltage data were analyzed by the categorical values of this score. Results Post-ablation recurrence (31.6% vs. 18.1%, p=0.046) was observed more frequently in group 2. The mean area of the low-voltage zone was 75.64±24.81 cm2 and 94.44±28.09 cm2 in groups 1 and 2, respectively (p=0.005). The left atrial mean voltage in group 2 was 0.99±0.31 mV, significantly lower than that (1.49±0.67 mV, p=0.001) in group 1. The CHA2 DS2-VASc score was the independent predictor with a modest predictive value for AF recurrence after catheter ablation. Conclusion Our study showed that CHA2 DS2-VASc score was associated with atrial remodeling and could be useful in stratifying post-ablation recurrence in patients with non-valvular AF.
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Lee et al. (2017) conducted a cohort in Non-valvular atrial fibrillation (n=151). CHA2DS2-VASc score ≥2 vs. CHA2DS2-VASc score <2 was evaluated on Post-ablation recurrence of atrial fibrillation (p=0.046). A CHA2DS2-VASc score ≥2 was associated with a significantly higher rate of atrial fibrillation recurrence after catheter ablation compared to a score <2 (31.6% vs. 18.1%, p=0.046).
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