Key result
Follow-up CT angiography at 17 months in patients with ACS after PCI revealed a significant increase in non-culprit plaque stenosis (58.3% to 60.4%, p=0.049) and plaque burden (p=0.043).
Why the study?
To evaluate the dynamics of coronary atherosclerotic plaques in patients with ACS using CT angiography.
Does computed tomography angiography detect changes in atherosclerotic plaque structure and instability signs over time in patients with ACS after PCI?
Observational (n=40)
Does computed tomography angiography detect changes in atherosclerotic plaque structure and instability signs over time in patients with ACS after PCI?
p-value: p=0.049
CT angiography demonstrates that non-culprit atherosclerotic plaques in ACS patients continue to progress in stenosis and burden over 17 months despite PCI of the culprit lesion, with dynamic changes in instability signs.
Serial CT angiography detects non-culprit plaque progression after ACS PCI; hypothesis-generating and should not yet change practice.
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Semenova et al. (2021) conducted an observational in Acute coronary syndrome (n=40). Computed tomography angiography (CTA) was evaluated on Degree of stenosis at the plaque level (p=0.049). Follow-up CT angiography at 17 months in patients with ACS after PCI revealed a significant increase in non-culprit plaque stenosis (58.3% to 60.4%, p=0.049) and plaque burden (p=0.043).
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