What question did this study set out to answer?

The aim is to evaluate the efficacy of fluorouracil alone compared to the combination with leucovorin calcium in advanced colorectal cancer.

March 1, 1990Journal of Clinical Oncology

Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy.

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Authors

JDJames H. DoroshowCardio-Oncology PMP MulthaufCity Of Hope National Medical Center LLL. LeongUniversity of Macau

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Implication

Randomized trial compares fluorouracil alone versus fluorouracil plus leucovorin in colorectal cancer, highlighting improved effectiveness with combination treatment.

Key Points

The aim is to evaluate the efficacy of fluorouracil alone compared to the combination with leucovorin calcium in advanced colorectal cancer.
79 patients with advanced colorectal cancer were randomly assigned to receive either fluorouracil or fluorouracil with leucovorin.
Leucovorin was administered at 500 mg/m2/d, starting 24 hours before fluorouracil and continuing 12 hours after.
Patients with disease progression on fluorouracil alone could cross over to the combination treatment.
Response rates for fluorouracil plus leucovorin were 44% compared to 13% for fluorouracil alone (P = .0019).
The median time to progression or death was 164 days for the leucovorin group versus 120 days for the fluorouracil group (log-rank, P = .045).
Overall survival was longer in the combination group, but not significantly different.

Cite This Study

Doroshow et al. (1990) studied this question.

synapsesocial.com/papers/6a1b78c239ea7417dc42e03f https://doi.org/10.1200/jco.1990.8.3.491

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Implication

Randomized trial compares fluorouracil alone versus fluorouracil plus leucovorin in colorectal cancer, highlighting improved effectiveness with combination treatment.

Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy.

Discussion

Member takes

Implication

Key Points

Cite This Study

Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy.

Discussion

Member takes

Implication

Key Points

Cite This Study

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