Why the study?
Does mid-late systolic mitral regurgitation result in more benign consequences and outcomes compared to holosystolic mitral regurgitation in patients with mitral valve prolapse?
Does mid-late systolic mitral regurgitation result in more benign consequences and outcomes compared to holosystolic mitral regurgitation in patients with mitral valve prolapse?
In patients with mitral valve prolapse, mid-late systolic mitral regurgitation yields lower regurgitant volume and more benign clinical outcomes compared to holosystolic MR, despite similar effective regurgitant orifice areas.
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May indicate lower event risk with mid-late versus holosystolic MR under medical management; leaves open whether timing should alter risk stratification or therapy in mitral valve prolapse.
Topilsky et al. (2012) studied this question.
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