Mitral Annular Dynamics in Myxomatous Valve Disease
Why the study?
Does real-time 3-dimensional transesophageal echocardiography reveal differences in mitral annular dynamics between patients with myxomatous valve disease, normal controls, and ischemic mitral regurgitation?
Population
32 patients with myxomatous valve disease and moderate to severe regurgitation, 15 normal control subjects…
Comparison
Real-time 3-dimensional transesophageal… vs Normal control subjects and patients with…
Design
Cross-sectional
Key result
Myxomatous valve disease was associated with early-systolic intercommissural dilatation (P=0.02) and loss of normal area contraction (P=0.99) and saddle-shape deepening (P=0.35).
Authors
Discussion
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Overview
Early intercommissural dilatation may occur in myxomatous valves; hypothesis-generating and requires prospective validation.
Study Design
Type
Observational (n=57)
Structured PICO
Does real-time 3-dimensional transesophageal echocardiography reveal differences in mitral annular dynamics between patients with myxomatous valve disease, normal controls, and ischemic mitral regurgitation?
P
Population
57 subjects comprising 32 patients with myxomatous valve disease and moderate to severe regurgitation, 15 normal controls, and 10 patients with ischemic mitral regurgitation.
E
Exposure
Real-time 3-dimensional transesophageal echocardiography (RT-3D TEE)
C
Comparator
Normal control subjects and patients with ischemic mitral regurgitation
O
Outcome
Mitral annular dimensions (circumference, area, anteroposterior and intercommissural diameters, height, and ratio of height to intercommissural diameter ratio) throughout the cardiac cyclesurrogate
Real-time 3D TEE demonstrates that myxomatous mitral valve disease is associated with loss of early-systolic area contraction and saddle-shape deepening, suggesting ventricular-annular decoupling.
Cite This Study
Grewal et al. (2010) conducted an observational in Myxomatous valve disease (n=57). Myxomatous valve disease vs. Normal controls and ischemic mitral regurgitation was evaluated on Mitral annular dimensions and dynamics throughout the cardiac cycle. Myxomatous valve disease was associated with early-systolic intercommissural dilatation (P=0.02) and loss of normal area contraction (P=0.99) and saddle-shape deepening (P=0.35).