Answers are grounded in this paper and cite their sources.
Nick of time: The nickel cyanomethyl complex 1 catalyzes the room temperature coupling of aldehydes with acetonitrile under base-free conditions. The catalytic system is long-lived and remarkably efficient with high turnover numbers (TONs) and turnover frequencies (TOFs) achieved. The mild reaction conditions allow a wide variety of aldehydes, including base-sensitive ones, to catalytically react with acetonitrile.
No takes yet. Share an insight, caveat, or question.
Chakraborty et al. (2013) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: