What does this research mean for the field?

The beneficial effects of converting enzyme inhibitors on post-ischemic ventricular arrhythmias, cardiac function, and metabolism are mediated by local cardiac enzyme inhibition that reduces Angiotensin II generation and prevents Bradykinin degradation. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1987Journal of Cardiovascular Pharmacology

Influence of Local Converting Enzyme Inhibition on Angiotensin and Bradykinin Effects in Ischemic Rat Hearts

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Population

Ischemic isolated perfused working rat hearts

Comparison

Perfusion with ramiprilat or pretreatment with… vs Untreated control hearts

Design

Preclinical

Follow-up

15 min occlusion followed by reperfusion

Authors

WLWolfgang LinzOntario Brain Institute BSBernward A. SchölkensGoethe University Frankfurt

Discussion

Member takes

Implication

Supports local ACE inhibition against reperfusion arrhythmias in rat hearts; leaves open clinical translation.

Structured PICO

Population

Ischemic isolated perfused working rat hearts (acute regional myocardial ischemia induced by 15 min occlusion of the left coronary artery followed by reperfusion)

Intervention

Perfusion with ramiprilat (100 ng/ml) or pretreatment with ramipril (1 mg/kg p.o.), with or without addition of angiotensin I, angiotensin II, or bradykinin

Comparator

Untreated control hearts

Outcome

Ventricular fibrillation during reperfusionsurrogate

Local converting enzyme inhibition protects against reperfusion arrhythmias and improves metabolic parameters in ischemic rat hearts by reducing local ANG II generation and BK degradation.

Cite This Study

Linz et al. (1987) studied this question.

synapsesocial.com/papers/6a1b7f3c39ea7417dc42e82e https://doi.org/10.1097/00005344-198706107-00012

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Influence of Local Converting Enzyme Inhibition on Angiotensin and Bradykinin Effects in Ischemic Rat Hearts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Influence of Local Converting Enzyme Inhibition on Angiotensin and Bradykinin Effects in Ischemic Rat Hearts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider