Population
Isolated rat heart model
Comparison
30 minutes of complete global ischemia followed… vs Preischemic control period
Design
Preclinical
Follow-up
30 minutes of ischemia and 30 minutes of reperfusion
Authors
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Ischemia-reperfusion stiffness rise may link to no-reflow in animals; leaves open clinical relevance and requires human validation.
Global ischemia and reperfusion markedly decrease passive ventricular compliance and increase contracture, which may contribute to the no-reflow phenomenon.
Apstein et al. (1977) studied this question.
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