March 1, 1976Annals of Internal Medicine
Diastolic Properties of the Left Ventricle
Design
Review
Authors
Discussion
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Implication
Diastolic properties contribute to HF symptoms; supports reevaluation of mechanisms but leaves open targeted interventions.
Key Points
- To review the mechanical and physiological determinants of left ventricular diastolic pressure and volume and evaluate how altered diastolic properties contribute to cardiac failure.
- Synthesized physiological principles of myocardial relaxation, chamber elasticity, and viscous and inertial ventricular properties across cardiac disease states.
- Acute myocardial ischemia impairs myocardial relaxation, directly distorting normal ventricular diastolic pressure-volume relationships.
- Aortic stenosis, coronary disease, and infiltrative cardiomyopathies increase chamber stiffness, requiring elevated left atrial pressure to maintain adequate end-diastolic sarcomere stretch.
- Loss of effective atrial contraction during atrial fibrillation or nodal rhythm triggers acute clinical deterioration in stiff ventricles, indicating that many heart failure symptoms arise from diastolic rather than systolic impairment.
Cite This Study
William Grossman (1976) studied this question.