Key result
Valvular aortic stenosis with concentric hypertrophy elevates diastolic filling pressures due to increased muscle mass and, in a subset of patients, augmented muscle stiffness.
Why the study?
What are the determinants of elevated diastolic pressures and ventricular stiffness in patients with valvular aortic stenosis and left ventricular hypertrophy?
Population
17 patients total: 4 subjects with normal LV function and 13 subjects with valvular aortic stenosis and…
Comparison
Simultaneous catheter micromanometry and LV… vs Subjects with normal LV function vs. patients…
Design
Cross-sectional
Authors
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Myocardial stiffness evaluation may refine diastolic assessment in aortic stenosis beyond hypertrophy alone; leaves open reversibility after valve replacement in prospective cohorts.
Observational (n=17)
What are the determinants of elevated diastolic pressures and ventricular stiffness in patients with valvular aortic stenosis and left ventricular hypertrophy?
Elevated diastolic filling pressures in aortic stenosis are driven by both concentric hypertrophy and, in a subset of patients, augmented but potentially reversible myocardial stiffness.
Peterson et al. (1978) conducted an observational in Valvular aortic stenosis and left ventricular hypertrophy (n=17). Valvular aortic stenosis and concentric myocardial hypertrophy vs. Normal LV function was evaluated on Left ventricular chamber and myocardial stiffness. Valvular aortic stenosis with concentric hypertrophy elevates diastolic filling pressures due to increased muscle mass and, in a subset of patients, augmented muscle stiffness.
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