Determinants of ventricular function in pressure-overload hypertrophy in man.
Population
14 patients with isolated aortic stenosis and various degrees of left ventricular failure, and 6 normal…
Design
Cross-sectional
Authors
Discussion
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Implication
May indicate inadequate hypertrophy drives systolic dysfunction in aortic stenosis; leaves open whether wall-stress reduction improves outcomes.
Structured PICO
P
Population
14 patients with isolated aortic stenosis and various degrees of left ventricular failure (ejection fraction range 0.19-0.85), and 6 normal control subjects
O
Outcome
Correlation between hemodynamic/geometric factors (circumferential wall stress, h/R ratio) and measures of ventricular function (ejection fraction, velocity of fiber shortening)surrogate
Impaired cardiac performance in patients with pressure-overload hypertrophy due to aortic stenosis is closely correlated with inadequate hypertrophy and high wall stress rather than depressed myocardial contractility.
Cite This Study
Gunther et al. (1979) studied this question.