November 1, 1974Circulation Research
Left Ventricular Stiffness Associated with Chronic Pressure and Volume Overloads in Man
Why the study?
How do chronic pressure and volume overloads affect left ventricular diastolic chamber stiffness and wall thickness?
Population
27 patients with chronic pressure overload, chronic volume overload, or normal controls
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
These cross-sectional associations should not change practice; leaves open longitudinal validation of stiffness as a therapeutic target.
Structured PICO
How do chronic pressure and volume overloads affect left ventricular diastolic chamber stiffness and wall thickness?
P
Population
27 patients with chronic pressure overload, chronic volume overload, or normal controls
C
Comparator
Control group (normal ventricles)
O
Outcome
Left ventricular diastolic chamber stiffness (slope of the left ventricular pressure-diameter relation in late diastole)surrogate
Chronic pressure overload is associated with a marked increase in intrinsic left ventricular chamber stiffness and wall thickness, whereas volume overload results in only slight increases.
Cite This Study
Grossman et al. (1974) studied this question.