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March 1, 1973Circulation

Quantitative Assessment of Left Ventricular Diastolic Stiffness in Man

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Population

23 patients without regional abnormalities of contraction

Design

Cross-sectional

Key result

Patients with left ventricular hypertrophy had significantly greater late diastolic stiffness (ΔP/ΔD = 6.1 ± 1.1 mm Hg/mm) compared to those without hypertrophy (1.8 ± 0.2 mm Hg/mm, P<0.001).

Authors

WGWilliam GrossmanMSMiltiadis A. StefadourosLMLambert P. McLaurin

Discussion

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Overview

LV hypertrophy links to higher diastolic stiffness via echo-pressure measures; hypothesis-generating and requires prospective validation before clinical use.

Key Points

  • This study aims to quantitatively assess left ventricular diastolic stiffness using specific pressure and volume metrics.
  • Utilized ultrasonic recordings of LV dimensions, pressures, and ECG.
  • Measured LV pressure and internal diameter at key points during left atrial systole in 23 patients.
  • Calculated stiffness ratios ΔP/ΔD and ΔP/ΔV to evaluate late diastolic stiffness.
  • Patients with LV hypertrophy exhibited significantly higher late diastolic stiffness (ΔP/ΔD = 6.1, ΔP/ΔV = 1.0) compared to those without (ΔP/ΔD = 1.8, ΔP/ΔV = 0.29, P < 0.001).
  • Patients with aortic stenosis had the highest stiffness metrics (ΔP/ΔD = 8.9, ΔP/ΔV = 1.5), while mitral stenosis showed the lowest (ΔP/ΔD = 1.5, ΔP/ΔV = 0.23).
  • Variations in stiffness ratios highlighted differences linked to underlying heart diseases.

Study Design

Type

Observational (n=23)

Structured PICO

P
Population
23 patients without regional abnormalities of contraction
I
Intervention
Quantitative assessment of left ventricular diastolic stiffness using simultaneous ultrasonic LV dimensions, LV pressure, and ECG
O
Outcome
Left ventricular diastolic stiffness (ΔP/ΔD and ΔP/ΔV) late in diastolesurrogate

Main Result

Absolute Event Rate: 6.1% vs 1.8%

p-value: p=<0.001

Simultaneous echocardiography and pressure recordings can quantitatively assess LV diastolic stiffness, which correlates well with LV hypertrophy and underlying pathophysiology.

Cite This Study

Grossman et al. (1973) conducted an observational in Left ventricular hypertrophy (n=23). Left ventricular hypertrophy vs. No left ventricular hypertrophy was evaluated on Late diastolic stiffness (ΔP/ΔD) (p=<0.001). Patients with left ventricular hypertrophy had significantly greater late diastolic stiffness (ΔP/ΔD = 6.1 ± 1.1 mm Hg/mm) compared to those without hypertrophy (1.8 ± 0.2 mm Hg/mm, P<0.001).

synapsesocial.com/papers/6a0eb10a06ecbe833447b40dhttps://doi.org/10.1161/01.cir.47.3.567
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The A Wave of the Apexcardiogram and Left Ventricular Diastolic Stiffness1974 · 31 citations
  2. 2Methods for Assessing Left Ventricular Diastolic Distensibility2024
  3. 3Doppler indexes of left ventricular systolic and diastolic function in relation to the arterial stiffness in a general population2016 · 38 citations
  4. 4Methods for assessing the diastolic distensibility of the left ventricle2024
  5. 5Diastolic left ventricular pressure-volume and stress-strain relations in patients with valvular aortic stenosis and left ventricular hypertrophy.1978 · 165 citations