What does this research mean for the field?

In subjects with congenital heart disease, chronic volume overload increases left heart volumes, whereas chronic pressure overload does not, and total left ventricular ejection volume maintains a nearly constant proportion to end-diastolic volume regardless of pressure load. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1964CirculationOpen Access

Effect of Chronic Pressure and Volume Overload on Left Heart Volumes in Subjects with Congenital Heart Disease

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Why the study?

Does chronic pressure or volume overload alter left heart volumes in subjects with congenital heart disease?

Population

n=50 subjects with congenital heart disease

Comparison

Chronic pressure or volume overload vs Subjects with no abnormality of the left heart

Design

Cross-sectional

Authors

GMGraham MillerAnalog Devices (United States)HSH.J.C. SwanAustralian Regenerative Medicine Institute

Discussion

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Implication

Volume overload but not pressure overload increases left heart volumes in congenital heart disease; hypothesis-generating for remodeling thresholds and outcomes.

Key Points

This research aims to assess the effect of chronic pressure and volume overload on left heart volumes in subjects with congenital heart disease.
Subjects included 50 individuals with varying heart conditions: normal, pressure overload, and volume overload.
Angiographic measurements were used to evaluate left heart volumes across these groups.
A linear relationship was assessed between end-diastolic and end-systolic volumes.
Left heart volumes remained normal in subjects with pressure overload.
In volume overload cases, end-diastolic, end-systolic, and atrial volumes exceeded normal limits.
A nearly constant proportion of total left ventricular ejection volume to end-diastolic volume was observed in most cases.

Structured PICO

Does chronic pressure or volume overload alter left heart volumes in subjects with congenital heart disease?

Population

n=50 subjects with congenital heart disease (18 with no left heart abnormality, 12 with left ventricular pressure overload, 20 with left ventricular volume overload)

Intervention

Chronic pressure or volume overload (observational)

Comparator

Subjects with no abnormality of the left heart

Outcome

Left heart volumes (end-diastolic, end-systolic, and atrial volumes) determined angiographicallysurrogate

Volume overload, but not pressure overload, leads to increased left heart volumes in congenital heart disease, while ejection fraction remains relatively constant.

Cite This Study

Miller et al. (1964) studied this question.

synapsesocial.com/papers/6a1577f9d64fa333899fb477 https://doi.org/10.1161/01.cir.30.2.205

Topics

Congenital heart disease adults

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Implication

Volume overload but not pressure overload increases left heart volumes in congenital heart disease; hypothesis-generating for remodeling thresholds and outcomes.

Effect of Chronic Pressure and Volume Overload on Left Heart Volumes in Subjects with Congenital Heart Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Effect of Chronic Pressure and Volume Overload on Left Heart Volumes in Subjects with Congenital Heart Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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