Key result
Treating extrinsic factors proves more successful than targeting intrinsic LV abnormalities for diastolic dysfunction symptoms.
Design
Review
Authors
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May guide symptom management toward extrinsic factors; leaves open whether intrinsic myocardial therapies will prove effective.
Diastolic dysfunction causes heart failure symptoms through intrinsic and extrinsic mechanisms, with extrinsic factors currently being more amenable to treatment.
Litwin et al. (1993) conducted a review in Heart failure and diastolic dysfunction. Diastolic dysfunction causes heart failure symptoms through intrinsic left ventricular abnormalities and extrinsic factors, with treatment of extrinsic factors currently being more successful.
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