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October 1, 1993Journal of the American College of CardiologyOpen Access

Diastolic dysfunction as a cause of heart failure

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Key result

Treating extrinsic factors proves more successful than targeting intrinsic LV abnormalities for diastolic dysfunction symptoms.

Design

Review

Authors

SLSheldon E. LitwinHeart Failure / Cardiomyopathy
William Grossman
William GrossmanBoston University

Discussion

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Overview

May guide symptom management toward extrinsic factors; leaves open whether intrinsic myocardial therapies will prove effective.

PICO

P
Population
Heart failure and diastolic dysfunction

Diastolic dysfunction causes heart failure symptoms through intrinsic and extrinsic mechanisms, with extrinsic factors currently being more amenable to treatment.

Cite This Study

Litwin et al. (1993) conducted a review in Heart failure and diastolic dysfunction. Diastolic dysfunction causes heart failure symptoms through intrinsic left ventricular abnormalities and extrinsic factors, with treatment of extrinsic factors currently being more successful.

synapsesocial.com/papers/6aa22d0d57affa4c5d46f406https://doi.org/10.1016/0735-1097(93)90463-b

Topics

Heart failureHFrEF treatment
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Also Consider

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  1. 1Determinants of left ventricular filling and of the diastolic pressure-volume relation.1989 · 366 citations
  2. 2Simultaneous assessment of left ventricular systolic and diastolic dysfunction during pacing-induced ischemia.1985 · 249 citations
  3. 3Contractility and stiffness of noninfarcted myocardium after coronary ligation in rats. Effects of chronic angiotensin converting enzyme inhibition.1991 · 132 citations
  4. 4The Effects of Antihypertensive Therapy on Left Ventricular Mass in Elderly Patients1990 · 248 citations
  5. 5Calcium-Antagonist Receptors in the Atrial Tissue of Patients with Hypertrophic Cardiomyopathy1989 · 98 citations