June 24, 2004Circulation Research
What Mechanisms Underlie Diastolic Dysfunction in Heart Failure?
Population
Heart failure patients, particularly those with preserved systolic function
Design
Review
Authors
Discussion
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Member takes
Implication
Incomplete mechanistic understanding of diastolic dysfunction cautions against premature HFpEF targeting; leaves open identification of regulators and therapies.
Structured PICO
P
Population
Heart failure patients, particularly those with preserved systolic function
This review highlights the need for a better understanding of the mechanisms underlying diastolic dysfunction, particularly chamber stiffness, to identify novel therapeutic targets for heart failure with preserved ejection fraction.
Cite This Study
Kass et al. (2004) studied this question.