Maternal cardiac arrhythmia in congenital heart disease: identifying high-risk pregnancy indicators

BACKGROUND: The onset of arrhythmia during pregnancy has been noted as a significant issue in clinical management of adult congenital heart disease. The authors sought to examine the actual incidence of arrhythmias in CHD patients during pregnancy, as well as to distinguish prognostic predictors of arrhythmia in CHD pregnant patients, specifically focusing on the predictive value of echocardiographic parameters. METHODS: This retrospective study involved 244 pregnant patients with CHD in a tertiary hospital. Baseline characteristics and clinical presentation were systemically compared between the arrhythmia group and no arrhythmia group. Univariate analyses were performed to identify baseline characteristics and hemodynamic parameters associated with outcomes. Subsequent multivariate logistic regression model identified the adjusted odds ratio (aOR) and 95% CI to pinpoint the independent risk factors of arrhythmia in CHD pregnancy. RESULTS: = 0.000) than the no arrhythmia group. Multivariate logistic regression identified parity (aOR:1.895[95%CI: 1.033-3.478]), left atrium size (aOR:1.089[95%CI: 1.008-1.175]), and moderate atrioventricular valve regurgitation (aOR:3.317[95%CI: 1.272-8.647]) as independent contributors for arrhythmia during CHD pregnancy. CONCLUSION: Early identification of risk factors that may predispose to arrhythmias favorably impacts long-term arrhythmia incidence and maternal neonatal outcome.