Electrical Substrate Ablation for Refractory Ventricular Fibrillation

Background: Refractory ventricular fibrillation (VF) is a challenging clinical entity, for which ablation of triggering premature ventricular complexes is described. When premature ventricular complexes are infrequent and multifocal, the optimal treatment strategy is uncertain. Methods: We prospectively enrolled consecutive patients presenting with multiple implantable cardioverter-defibrillator shocks for VF refractory to antiarrhythmic drug therapy, exhibiting infrequent (≤3%), multifocal premature ventricular complexes (≥3 morphologies). Procedurally, VF was induced with rapid pacing and mapped, identifying sites of conduction slowing and rotation or rapid focal activation. VF electrical substrate ablation was then performed. Outcomes were compared against reference patients with VF who were unable or unwilling to undergo catheter ablation. The primary outcome was a composite of implantable cardioverter-defibrillator shock, electrical storm, or all-cause mortality. Results: VF was induced and mapped in 6 patients (60±10 years; left ventricular ejection fraction, 46±19%) with ischemic (n=3) and nonischemic cardiomyopathy. An average of 3.3±0.5 sites of localized reentry during VF were targeted for radiofrequency ablation (38.3±10.9 minutes) during sinus rhythm, rendering VF noninducible with pacing. Freedom from the primary outcome was 83% in the VF ablation group versus 17% in 6 nonablation reference patients at a median of 1.0 years (interquartile range, 0.5–1.5 years; P =0.046) of follow-up. Conclusions: VF electrical substrate ablation is associated with a reduction in the combined end point compared with the nonablation reference group. Additional work is required to understand the precise pathophysiologic changes that promote VF to improve preventative and therapeutic strategies.