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October 4, 2016Journal of Pharmacy TechnologyOpen Access

Of the reviewed charts, 25% of prescribed DOACs should have been avoided, 24% were inappropriate due to dosing or interactions, and 19% of patients on warfarin were candidates for DOAC therapy.

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Why the study?

Does pharmacist intervention identify and improve the appropriateness of DOAC and warfarin prescribing in adult outpatients?

Population

175 adult patients receiving a direct oral anticoagulant or warfarin therapy in a university-affiliated…

Design

Cohort

Authors

HPHaley M. PhillippeBWBradley M. WrightKBKathryn E. Bowerman

Discussion

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Overview

Pharmacist-led outpatient reviews detect frequent inappropriate DOAC use; hypothesis-generating for monitoring programs pending prospective trials.

Structured PICO

Does pharmacist intervention identify and improve the appropriateness of DOAC and warfarin prescribing in adult outpatients?

P
Population
175 adult patients receiving a direct oral anticoagulant (apixaban, rivaroxaban, dabigatran) or warfarin therapy in a university-affiliated outpatient clinic
I
Intervention
Pharmacist review of patient charts and verbal recommendations to primary care prescribers regarding the appropriateness of anticoagulant therapy
O
Outcome
Appropriateness of DOAC and warfarin therapy based on indication, dose, duration, age, weight, adherence, drug interactions, bleeding risk/history, renal function, and hepatic function

Pharmacist-led medication reviews in an outpatient setting identified high rates of inappropriate DOAC prescribing, highlighting the need for dedicated monitoring and prescriber education.

Cite This Study

Phillippe et al. (2016) studied this question.

synapsesocial.com/papers/6a1b830447464d53695f40a0https://doi.org/10.1177/8755122516672693
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