What does this research mean for the field?

Phenylindanedione is an effective anticoagulant that alters the one-stage prothrombin time, producing a clinical effect similar to dicoumarol but with a more rapid and less prolonged action. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1954Journal of Clinical PathologyOpen Access

The Mode of Action of Phenylindanedione

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Why the study?

Does Phenylindanedione alter prothrombin time similarly to dicoumarol in the treatment of thrombosis?

Comparison

Phenylindanedione (P.I.D.) vs Dicoumarol

Design

Review

Authors

WWWilliam F. WalkerAuburn University RHR. B. HunterGuy's Hospital

Discussion

Member takes

Implication

May inform anticoagulant timing considerations; leaves open prospective validation versus modern agents.

Structured PICO

Does Phenylindanedione alter prothrombin time similarly to dicoumarol in the treatment of thrombosis?

Intervention

Phenylindanedione (P.I.D.)

Comparator

Dicoumarol

Outcome

Alteration of one-stage prothrombin timesurrogate

Phenylindanedione is an effective anticoagulant that alters prothrombin time more rapidly and for a shorter duration than dicoumarol.

Limitations

Sufficient experience has not yet been accumulated to compare its efficacy with tromexan (ethyl-biscoumacetate)

Cite This Study

Walker et al. (1954) studied this question.

synapsesocial.com/papers/6a1b896b39ea7417dc42f4de https://doi.org/10.1136/jcp.7.3.249

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The Mode of Action of Phenylindanedione

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

The Mode of Action of Phenylindanedione

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider