Why the study?
Does an increase in plasma free fatty acids following intravenous heparin injection correlate with platelet aggregation in healthy adults?
Does an increase in plasma free fatty acids following intravenous heparin injection correlate with platelet aggregation in healthy adults?
Intravenous heparin-induced increases in free fatty acids correlate with primary, but not secondary, platelet aggregation in healthy adults.
Heparin-induced free fatty acid rises associate with primary platelet aggregation in healthy adults; hypothesis-generating, should not yet change practice.
Platelet aggregation was studied following intravenous injection of heparin to nine healthy adults. Heparin is known to produce an increase in the concentration of free fatty acids (FFA) within 10 minutes of intravenous injection. A significant correlation was found between the intensity of primary platelet aggregation and changes in plasma FFA levels. No correlation was found between plasma FFA levels and the intensity of secondary platelet aggregation.
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Burstein et al. (1978) studied this question.
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