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PURPOSE: To report the immunosuppressive property of dry human amniotic membrane (dHAM). METHODS: Mouse splenocytes harvested from Balb/c mice were stimulated using functional-grade anti-CD3e antibodies for 4 days either with or without either of 2 commercial types of dHAM (Ambiodry 1 & 2, IOP Inc., Costa Mesa, Calif., USA) added to the culture media. The cell proliferation assay was performed to analyze the extent of splenocyte proliferation. RESULTS: dHAMs significantly suppressed mouse splenocyte proliferation compared to control. The suppression by dHAM with intact amniotic epithelium (Ambiodry 2) was significantly stronger than dHAM without epithelium (Ambiodry 1). CONCLUSION: The immunosuppressive property of dHAM was demonstrated using an alloreactive splenocyte proliferation assay.
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Park et al. (2008) studied this question.
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