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Autonomic factors may refine LQTS risk stratification; leaves open prospective trials of targeted modulation.
Autonomic Modulation of Repolarization. The modulation of repolarization on ECG, the currents contributing to it in cardiac myocytes, and the effects of autonomic stimulation on repoiarization are all complex areas that not only influence the normal rhythm of the heart, but have important implications with respect to arrhythmias. The following is a brief review that stresses the role of autonomic modulation of repolarization, summarizing the extent of our information with respect to the normal heart and the dysrhythmic heart. Particular emphasis is placed on the long QT syndrome and its relationship to lethal arrhythmias. ( J Cardiovasc Electrophysiol, Vol. 3, pp. 487–499. October 1992 )
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Rosen et al. (1992) studied this question.
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