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The aim is to investigate histone gene expression and the 3' end structure of histone mRNA during C. elegans development.

January 1, 2007BMC Molecular BiologyOpen Access

Histone gene expression and histone mRNA 3' end structure in Caenorhabditis elegans

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The aim is to investigate histone gene expression and the 3' end structure of histone mRNA during C. elegans development.
Sequence analysis of replication-dependent histone genes
Poly(A) selection and RNAse protection
RNA sequencing of histone mRNA ends
Majority of C. elegans histone mRNAs lack a poly(A) tail and end three to six nucleotides after the hairpin structure.
Histone gene expression is reduced in L3 compared to L1 and adult stages; restricted to the germ line in adults.
RNAi knockdown of CDL-1 does not affect mRNA levels but severely depletes histone protein levels.

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Randomized trial reveals histone gene expression patterns in C. elegans, suggesting regulation during development.

Keall et al. (2007) studied this question.

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