What does this research mean for the field?

Murine ACE exhibits species-specific receptor-like properties, initiating intracellular signaling and enhancing cyclooxygenase-2 transcription through a mechanism where its two catalytic domains exhibit negative cooperativity rather than functioning independently. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 23, 2009Biological Chemistry

Signal transduction in CHO cells stably transfected with domain-selective forms of murine ACE

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Population

CHO cells stably transfected with murine ACE or its domain-selective mutants, and human umbilical vein…

Design

Preclinical

Authors

XSXiaoou SunGuangdong University of Technology BRBrit RentzschMax Delbrück Center MGMaolian GongMax Delbrück Center

Discussion

Member takes

Implication

ACE signaling via negative cooperativity is hypothesis-generating in animals; leaves open relevance to human ACE inhibitor effects.

Structured PICO

Population

CHO cells stably transfected with murine ACE (mACE) or its domain-selective mutants, and human umbilical vein endothelial cells

Intervention

Activation with ACE substrates, inhibitors, or angiotensin-II

Outcome

Signal transduction response (JNK and c-Jun activation, cyclooxygenase-2 transcription, and membrane-bound ACE activity)surrogate

This study demonstrates that ACE has receptor-like properties and initiates intracellular signaling via negative cooperativity between its two catalytic domains.

Cite This Study

Sun et al. (2009) studied this question.

synapsesocial.com/papers/6a1bb02227b545b111a8e27a https://doi.org/10.1515/bc.2010.020

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Signal transduction in CHO cells stably transfected with domain-selective forms of murine ACE

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Signal transduction in CHO cells stably transfected with domain-selective forms of murine ACE

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider