Postprandial effects of macronutrient composition meals on metabolic responses and arterial stiffness indexes in lean and obese men adults; a protocol study (Preprint)

BACKGROUND Background: Prior studies have shown that meal composition is capable of effect on metabolic response and arterial stiffness indexes. OBJECTIVE Objective: A three-phase parallel study will design to investigate the effects of meal composition on metabolic parameters and arterial stiffness indexes among lean and obese adult. The planned study protocol is presented METHODS Methods/design: This is a parallel clinical trial targeting adults (aged 18–35 years, free from any diseases) selected by inclusion and exclusion criteria at Mashhad University Medical Sciences. Each subject will complete three interventions with a washout period of one week: high carbohydrate, high protein and high fat meal. The postprandial effect will be assessed during 360 minutes from each meal including energy expenditure component, pulse wave analysis and pulse wave velocity and blood sampling. RESULTS N/A CONCLUSIONS Metabolic Responses, Macronutrients Composition, Arterial Stiffness, Study Protocol: The differences in postprandial response due to different meal composition could affect of metabolic and vascular parameters. This could provide necessary information for the establishment of new strategies in terms of nutritional education and metabolic and vascular improvement. CLINICALTRIAL Trial registration: Iranian Registry of Clinical Trials: IRCT20190818044552N1. Registered on August 26, 2019