Key Points
- To determine the sequence, pathways, and conduction velocity of electrical activation across the canine interventricular septum.
- Utilized multipolar recording techniques to record and map electrical excitation throughout the interventricular septum in canine hearts.
- Depolarization begins in the mid left septal endocardium and emerges shortly thereafter near the right anterior papillary muscle.
- Conduction spreads across endocardial surfaces at approximately 1 m/sec (likely via Purkinje tissue) and penetrates through the septal thickness at approximately 0.33 m/sec.
- Rapid endocardial conduction is absent in the upper septum bilaterally and along the posterior right septal surface.
Structured PICO
PPopulationCanine model (interventricular septum)
IInterventionMultipolar recording techniques to study excitation
OOutcomeSequence and speed of depolarization spread in the interventricular septumsurrogate
This preclinical study maps the activation sequence of the canine interventricular septum, demonstrating rapid endocardial conduction and slower transmural conduction.