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May 1, 1951Experimental Biology and Medicine

Excitation of the Isolated Ventricular Septum of the Heart

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Key result

Canine septal recordings reveal early left-sided and late right-sided activation, challenging the neutralization concept.

Population

Isolated perfused dog's ventricular septum

Design

Preclinical

Authors

HBHoward B. BurchellMayo ClinicRPR D PruittEmory UniversityHEHiram E. EssexUniversity of Minnesota

Discussion

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Implication

Challenges canine septal neutralization; leaves open relevance to human ventricular activation and conduction disorders.

Structured PICO

P
Population
Isolated perfused dog's ventricular septum
E
Exposure
Electrogram recording
O
Outcome
Electrogram patterns and excitatory pathwayssurrogate

Electrograms of isolated dog ventricular septa reveal complex activation patterns that challenge the theory of septal potential neutralization.

Cite This Study

Burchell et al. (1951) studied this question. Electrophysiological recording of isolated perfused dog's ventricular septum was evaluated on Electrophysiological activation pattern of the ventricular septum. Electrophysiological recordings of the isolated perfused dog's ventricular septum showed that the left side is activated early and the upper right side late, challenging the concept of neutralization.

synapsesocial.com/papers/6aa742cfd4c94fa098d3b797https://doi.org/10.3181/00379727-77-18697
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Studies on the Spread of Excitation through the Ventricular Myocardium1952 · 51 citations
  2. 2Activation of the Interventricular Septum1955 · 94 citations
  3. 3The Pathway of Ventricular Depolarization in the Dog1956 · 153 citations
  4. 4Total Excitation of the Isolated Human Heart1970 · 1,790 citations
  5. 5Physiology of Canine Intraventricular Conduction and Endocardial Excitation1972 · 195 citations