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June 14, 2018Frontiers in PhysiologyOpen Access

Recent Advances in Placenta–Heart Interactions

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Population

Fetuses and infants with or at risk for congenital heart defects (CHD)

Design

Review

Authors

CMCheryl L. MaslenOregon Health & Science University

Discussion

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Implication

Hypothesis-generating for placenta-heart axis in CHD; prospective studies needed before any clinical adoption.

Structured PICO

P
Population
Fetuses and infants with or at risk for congenital heart defects (CHD)

This review highlights the critical role of the placenta-heart axis in fetal development and suggests that placental insufficiency and shared genetic vulnerabilities may be key factors in the pathogenesis of congenital heart defects.

Cite This Study

Cheryl L. Maslen (2018) studied this question.

synapsesocial.com/papers/6a1bc295bc71fb1015a8ef09https://doi.org/10.3389/fphys.2018.00735

Topics

Congenital heart disease adults
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Also Consider

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  1. 1Maternal diabetes: An independent risk factor for major cardiovascular malformations with increased mortality of affected infants2001 · 217 citations
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  3. 3New syndrome? Ectrodactyly, retrognathism, abnormal ears, highly arched palate, spina bifida, congenital heart defect, single umbilical artery1991 · 10 citations
  4. 4Fetal Growth Restriction Results in Remodeled and Less Efficient Hearts in Children2010 · 436 citations
  5. 5Single umbilical artery and congenital heart disease in selected and unselected populations2010 · 25 citations