What does this research mean for the field?

Serum MMP-9 levels are significantly elevated in patients with previous acute myocardial infarction independently of other inflammatory markers, serving as a novel biomarker of inflammation and plaque activity in coronary artery disease. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate whether circulating matrix metalloproteinases, specifically MMP-2 and MMP-9, act as sensitive markers of vascular inflammation in patients with coronary artery disease.

September 1, 2003Journal of Investigative Medicine

Serum Metalloproteinase 9 Levels in Patients with Coronary Artery Disease: A Novel Marker of Inflammation

View Full Paper

Ask AI

Bookmark

Why the study?

Are serum MMP-9 levels elevated in patients with previous acute myocardial infarction compared to controls?

Population

132 subjects

Design

Case-control

Authors

PFPatrizia FerroniSan Raffaele University of Rome SBStefania BasiliVascular / Pulmonary Vascular FMFrancesca MartiniUniversity of Pisa

Discussion

Member takes

Implication

May support MMP-9 as post-MI inflammatory marker; hypothesis-generating, requires prospective validation before clinical use.

Key Points

To evaluate whether circulating matrix metalloproteinases, specifically MMP-2 and MMP-9, act as sensitive markers of vascular inflammation in patients with coronary artery disease.
Matched case-control study measuring serum levels of MMP-2, MMP-9, interleukin-6, C-reactive protein, and fibrinogen in 66 patients with prior acute myocardial infarction and 66 matched controls without atherothrombotic disease.
Conditional logistic regression was conducted to determine the independent association between MMP levels and myocardial infarction after adjusting for cardiovascular therapies and C-reactive protein.
Median serum MMP-9 concentrations were significantly elevated in cases compared to controls (40.6 vs. 9.8 ng/mL; p < .0001), whereas MMP-2 concentrations showed no significant difference (839 vs. 873 ng/mL; p = .53).
MMP-9 levels correlated directly with interleukin-6, C-reactive protein, and fibrinogen, and remained significantly associated with myocardial infarction in adjusted multivariable analysis (p = .006).

Structured PICO

Are serum MMP-9 levels elevated in patients with previous acute myocardial infarction compared to controls?

Population

132 subjects (66 cases with previous acute myocardial infarction and 66 control subjects similar for age, sex, and major atherosclerotic risk factors but without history or evidence of atherothrombotic diseases)

Comparator

Control subjects similar for age, sex, and major atherosclerotic risk factors but without history or evidence of atherothrombotic diseases

Outcome

Serum levels of MMP-2, MMP-9, interleukin-6, C-reactive protein, and fibrinogensurrogate

Serum MMP-9 levels are significantly elevated in patients with previous myocardial infarction, suggesting its potential as a novel marker of inflammation and plaque activity.

Cite This Study

Ferroni et al. (2003) studied this question.

synapsesocial.com/papers/6a1bc2d601af05bf0da8eaf7 https://doi.org/10.1136/jim-51-05-17

Topics

Coronary artery disease

View Full Paper

Ask AI

Bookmark