What question did this study set out to answer?

To determine whether accelerated protein degradation and defective glucose metabolism following severe thermal injury occur systemically in distant, uninjured skeletal muscle.

September 1, 1984Journal of Clinical InvestigationOpen Access

Systemic response to thermal injury in rats. Accelerated protein degradation and altered glucose utilization in muscle.

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To determine whether accelerated protein degradation and defective glucose metabolism following severe thermal injury occur systemically in distant, uninjured skeletal muscle.
Measured protein synthesis, protein degradation, and glucose metabolism in forelimb muscles of rats 48 hours following a scald injury to the hindquarters.
Evaluated metabolic responses across varying insulin doses and tested the mechanistic roles of adrenalectomy, prostaglandin synthesis inhibition (indomethacin), and lysosomal proteolysis inhibition (EP475).
Thermal injury increased muscle protein degradation from 140 ± 5 to 225 ± 5 nmol tyrosine/g per h without altering protein synthesis, alongside a >70% increase in muscle lactate release.
Burn injury reduced muscle glycogen synthesis responsiveness to insulin, increased net glycolysis and glucose oxidation, and produced a strong positive correlation between protein degradation and lactate release (r = +0.82, P < 0.01).
Catabolism was unaffected by adrenalectomy or indomethacin, but lysosomal inhibition via EP475 combined with insulin reduced protein degradation by 41%, and alpha-ketoisocaproate reduced degradation by 28% and lactate release by 56%.

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Implication

Experimental animal study reveals systemic muscle protein degradation and altered glucose catabolism in uninjured tissue of scalded rats, indicating widespread metabolic dysfunction.

Cite This Study

Clark et al. (1984) studied this question.

synapsesocial.com/papers/6a1bc3c9d54006be995eebb8 https://doi.org/10.1172/jci111506

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Implication

Experimental animal study reveals systemic muscle protein degradation and altered glucose catabolism in uninjured tissue of scalded rats, indicating widespread metabolic dysfunction.

Systemic response to thermal injury in rats. Accelerated protein degradation and altered glucose utilization in muscle.

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Discussion

Implication

Cite This Study

Systemic response to thermal injury in rats. Accelerated protein degradation and altered glucose utilization in muscle.

Key Points

Discussion

Implication

Cite This Study

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