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June 2, 2021Journal of the American Heart AssociationOpen Access

Low‐Level Tragus Stimulation Modulates Atrial Alternans and Fibrillation Burden in Patients With Paroxysmal Atrial Fibrillation

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Why the study?

P-wave alternans may share a substrate with AF and could serve as a marker to guide low-level tragus stimulation therapy in patients with AF.

Does low-level tragus stimulation reduce atrial fibrillation burden and P-wave alternans in patients with paroxysmal atrial fibrillation?

Comparison

Active LLTS vs sham (earlobe stimulation)

Design

Randomized controlled trial

Follow-up

6 months

Authors

KKKanchan KulkarniJSJagmeet P. SinghKPKimberly A. Parks

Discussion

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Member takes

Overview

Chronic LLTS reduces AF burden in paroxysmal AF; extends neuromodulation evidence for arrhythmia management.

Structured PICO

Does low-level tragus stimulation reduce atrial fibrillation burden and P-wave alternans in patients with paroxysmal atrial fibrillation?

P
Population
n=28 patients with paroxysmal atrial fibrillation
I
Intervention
Low-level tragus stimulation (LLTS) delivered through a transcutaneous electrical nerve stimulation device (pulse width 200 μs, frequency 20 Hz, amplitude 10-50 mA), for 1 hour daily over a 6-month period
C
Comparator
Sham (earlobe stimulation)
O
Outcome
Atrial fibrillation burden over 2-week periods assessed by noninvasive continuous ECG monitoring and P-wave alternans (PWA) burden at 6 monthssurrogate

Chronic, intermittent low-level tragus stimulation significantly reduces P-wave alternans and atrial fibrillation burden in patients with paroxysmal AF.

Cite This Study

Kulkarni et al. (2021) studied this question.

synapsesocial.com/papers/6a1bc41800ee29383e9cdac4https://doi.org/10.1161/jaha.120.020865
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