Why the study?
Although plasma fibrinogen levels and erythrocyte aggregation are positively associated with essential arterial hypertension, how the interaction between fibrinogen and its erythrocyte membrane receptor is altered remained unclear.
Are fibrinogen-erythrocyte binding and hemorheology altered in patients with essential arterial hypertension compared to healthy donors?
Population
31 EAH patients and 65 healthy blood donors
Comparison
Therapeutically controlled EAH patients vs healthy blood donors
Design
Case-control study
Authors
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May perturb microvascular flow in essential hypertension; hypothesis-generating for hemorheological mechanisms and targeted interventions.
Are fibrinogen-erythrocyte binding and hemorheology altered in patients with essential arterial hypertension compared to healthy donors?
Essential arterial hypertension is associated with stronger fibrinogen-erythrocyte binding forces and increased erythrocyte stiffness, which may contribute to blood flow perturbations and cardiovascular risk.
Guedes et al. (2019) studied this question.
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