The association of prolapse of the posterior cusp of the mitral valve and atrial septal defect is clinically significant for differentiating it from atrioventricular defects.
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May aid differentiation from atrioventricular defects; hypothesis-generating case observations requiring prospective confirmation.
Eleven patients with fossa ovalis atrial septal defects and prolapse of the posterior cusp of the mitral valve are described. Six patients had clinical evidence of mitral regurgitation, and in 2 others the electrocardiogram was unusual for uncomplicated fossa ovalis atrial septal defects. The varied appearance of the prolapsed cusp was shown by left ventricular angiography. The principal significance of this association is in its differentiation from atrioventricular defects.
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McDonald et al. (1971) studied this question.
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