Pathogenesis of a rarely occurring transient, isolated focal lesion of the splenium of the corpus callosum in epilepsy patients is uncertain: frequent seizures or antiepileptic drug reduction causing ischemia or demyelination is possible. The several MRI sequences, including diffusion-weighted imaging, in this first case of occipital epilepsy suggest ischemia from rapid carbamazepine reduction, frequent seizures, or a combination of both.
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Mirsattari et al. (2003) studied this question.