Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 1, 2009Rejuvenation Research

Subjects in the highest Lp(a) tertile (>20 mg/dL) had a higher fully adjusted risk of nonfatal CAD (HR 3.41; 95% CI 1.08-10.78) compared to the lowest tertile, with no significant association for all-cause mortality or cumulative fatal-nonfatal stroke and CAD events.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does high Lipoprotein(a) increase the risk of fatal and nonfatal vascular events or all-cause mortality in elderly individuals?

Population

372 elderly individuals, 169 women and 203 men, from one center of the Italian Longitudinal Study on Aging…

Comparison

Highest tertile of Lipoprotein serum levels vs Lowest tertile of Lipoprotein(a) serum levels

Design

Cohort

Follow-up

6.3-year median

Authors

VSVincenzo SolfrizziACAnna M. ColaciccoADAlessia D’Introno

Discussion

Loading...

Member takes

Overview

May refine nonfatal CAD risk assessment in elderly; leaves open whether Lp(a) lowering alters outcomes.

Structured PICO

Does high Lipoprotein(a) increase the risk of fatal and nonfatal vascular events or all-cause mortality in elderly individuals?

P
Population
372 elderly individuals (65-84 years), 169 women and 203 men, from one center of the Italian Longitudinal Study on Aging (ILSA) in Casamassima, Bari, Italy.
I
Intervention
Highest tertile of Lipoprotein(a) serum levels (>20 mg/dL)
C
Comparator
Lowest tertile of Lipoprotein(a) serum levels
O
Outcome
Competing risks of all-cause mortality, cumulative fatal-nonfatal stroke events, cumulative fatal-nonfatal coronary artery disease (CAD) events, and nonfatal stroke or CAD eventshard clinical

High Lipoprotein(a) levels (>20 mg/dL) are an independent predictor of nonfatal CAD, but not stroke or all-cause mortality, in an elderly Italian population when accounting for competing risks.

Cite This Study

Solfrizzi et al. (2009) studied this question.

synapsesocial.com/papers/6a1bc8adea84844e355ef3a4https://doi.org/10.1089/rej.2009.0865
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Significance of Serum Lipoprotein(a) Concentration in the Elderly with Regard to Vascular Complications and Long-term Prognosis.1999 · 1 citations
  2. 2The Additive Prognostic Value of Lipoprotein(a) for All-cause and Cardiovascular Mortality Across the Traditional Cardiovascular Risk Continuum: Analysis from NHANES III (1988–1994) with Follow-Up to 20192026 · 4 citations
  3. 3Lipoprotein (a) and 10-year Cardiovascular Disease Incidence in Apparently Healthy Individuals: A Sex-based Sensitivity Analysis from ATTICA Cohort Study2019 · 30 citations
  4. 4Lipoprotein(a) and Long-Term Cardiovascular Risk in a Multi-Ethnic Pooled Prospective Cohort2024 · 104 citations
  5. 5Lipoprotein(a) and Risk of Coronary, Cerebrovascular, and Peripheral Artery Disease2012 · 208 citations